"Within 3 months, I was able to completely change my bloodwork"
Assess your risk.
Unlock expert support.
Convenient APOE4 dementia genetic test
15-min online consultation with a dementia specialist
Access to our online dementia prevention center
Developed by top academics from around the world
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Science you can trust.
Results you can understand.
Advanced genetic testing with expert guidance.
The APOE4 gene is the most reliable genetic marker for dementia risk, backed by decades of research and thousands of studies. It’s directly linked to amyloid plaque buildup, tau tangles, and brain inflammation—key drivers of Alzheimer’s. Found in up to 25% of the population, its strong association with cognitive decline (up to a 20x higher risk) makes it the gold standard for genetic dementia testing.
Getting genetic results can feel overwhelming—but with BetterBrain, a dementia specialist is here to help you make sense of them. You'll receive your results in a personalized online consultation, where they’ll clearly explain what your results mean, what they imply for your brain health, and what your best next steps are.
Getting genetic results can feel overwhelming—but with BetterBrain, a dementia specialist is here to help you make sense of them. You'll receive your results in a personalized online consultation, where they’ll clearly explain what your results mean, what they imply for your brain health, and what your best next steps are.
Backed by 1,000+ studies
Detect up to 20x risk
Simple blood test
Results in 4 days or less
Don't just take our word for it
See what some of these leading physicians and researchers have to say about preventive neurology.
Andrew Huberman, PhD
''We know that if you adjust for the appropriate lifestyle factors early enough, you can offset most if not all the genetic predisposition to Alzheimer's.''
Tommy Wood, MD
''There was a Lancet Commission report in 2020 that estimated that 40% of dementia is preventable... My guess is that this is actually an underestimate because they didn’t include sleep, they didn’t include nutrient status, particularly homocysteine status, which other individuals have suggested has a population attributable risk of around 20% for late-onset Alzheimer’s disease''
Rhonda Patrick, MD
''Looking at Alzheimer's disease and understanding the underlying cause of it opens up these new avenues for prevention.''
David Sinclair, PhD
''It's not just about ourselves, it's about our families. Many families have had to take care of parents and grandparents that have dementia. This is not pleasant for anybody and we have a responsbility to society and particularly our family members to stay healthy for longer, particularly keeping our brains younger for longer''
Sanjay Gupta, MD
''One thing has become abundantly clearer: Preventing and even treating forms of dementia are largely driven by lifestyle and the choices we make daily. You are not necessarily doomed to whatever fate you think sits stuck in your genes.''
Although BetterBrain is not affiliated with any of these experts, we encourage you to familiarize yourself with their research, books, podcasts, and offerings.
How it works
Get tested. Get informed. Get ahead.
Order your blood test
Schedule a blood draw from 1 of our 2,000 partner labs, or choose an at-home blood draw for extra comfort.
Receive Your Results
Your results will be available within 2–4 days and a dementia specialist who will help you understand their meaning and implications.
Begin Your Prevention Journey
Uncovering a genetic risk doesn’t mean you’re powerless. Join BetterBrain’s prevention protocol to take control and actively reduce your risk.
Watching my mom decline with Alzheimer's was heartbreaking, and knowing that I am genetically at a higher risk for this awful disease scared me. BetterBrain helped me make changes in areas I didn’t even know I needed to work on. I now feel empowered to improve my health and encouraged that I’m on the right track. HIGHLY recommend.
Kim L.
How to interpret your results
While a specialist will go over your results with you in detail, here’s how the APOE test works to assess your risk.
No copy of APOE4
Approx. 75% of the population
No increased genetic risk for Alzheimer’s.
A negative test doesn’t necessarily preclude you from getting dementia, since half of Alzheimer’s patients are APOE4 negative (i.e., do not carry any APOE4 genes).
A negative test doesn’t necessarily preclude you from getting dementia, since half of Alzheimer’s patients are APOE4 negative (i.e., do not carry any APOE4 genes).
One copy of APOE4
Approx. 22% of the population
Risk is 2-3 times higher compared to non-carriers.
A comprehensive and rigorous prevention plan can practically eliminate the risk for single APOE4 carriers.
A comprehensive and rigorous prevention plan can practically eliminate the risk for single APOE4 carriers.
Two copies of APOE4
Approx. 2-3% of the population
Risk is approx. 12-20 times higher compared to non-carriers.
Prevention should be even more focused and tailored to manage and monitor the risk.
Prevention should be even more focused and tailored to manage and monitor the risk.
Genetic risk detected?
1 in 2 dementia cases can be prevented*
Science shows that with a personalized set of interventions, you can significantly reduce your risk of dementia.
88% of members in BetterBrain’s prevention program improved key dementia risk markers—in just 3 months.
*Source: The Lancet Commission on Dementia 2024 report
Don't just take our word for it
See what some of these leading physicians and researchers have to say about preventive neurology.
Andrew Huberman, PhD
''We know that if you adjust for the appropriate lifestyle factors early enough, you can offset most if not all the genetic predisposition to Alzheimer's.''
Tommy Wood, MD
''There was a Lancet Commission report in 2020 that estimated that 40% of dementia is preventable... My guess is that this is actually an underestimate because they didn’t include sleep, they didn’t include nutrient status, particularly homocysteine status, which other individuals have suggested has a population attributable risk of around 20% for late-onset Alzheimer’s disease''
Rhonda Patrick, MD
''Looking at Alzheimer's disease and understanding the underlying cause of it opens up these new avenues for prevention.''
David Sinclair, PhD
''It's not just about ourselves, it's about our families. Many families have had to take care of parents and grandparents that have dementia. This is not pleasant for anybody and we have a responsbility to society and particularly our family members to stay healthy for longer, particularly keeping our brains younger for longer''
Sanjay Gupta, MD
''One thing has become abundantly clearer: Preventing and even treating forms of dementia are largely driven by lifestyle and the choices we make daily. You are not necessarily doomed to whatever fate you think sits stuck in your genes.''
Although BetterBrain is not affiliated with any of these experts, we encourage you to familiarize yourself with their research, books, podcasts, and offerings.
“BetterBrain made it so easy to assess my risk & formulate a plan”
"They had the answer to every crazy question I had, and the science to back it up"
Find the plan that’s right for you
Genetic
risk assessment
risk assessment
BetterBrain
Advanced
Check-up
Advanced
Check-up
APOE4 genetic test
Understand your genetic risk for dementia
APOE4 (one copy): Approximately 25% of people carry 1 copy of the APOE4 variant, which increases Alzheimer's risk by 2-3 times compared to non-carriers.
APOE4/4 (two copies): About 2-3% of the population carries 2 copies of APOE4, which may increase risk by 12-20 times.
If you have the APOE4 variant, there are specific lifestyle changes that may be particularly beneficial for your brain health.
15min online consultation with a dementia specialist
15-mins virtual consultation with our dementia prevention specialist to explain the results of the genetic test.
Science-backed dementia
prevention protocol
Brain health assessment
(blood test of 50+ biomarkers)
50+ blood tests, many not typically covered in primary care
Blood panel curated by our panel of cross-speciality physicians
Use one of 2,000+ LabCorp locations, or from your home (where available)
98% of appointments vailable next day
Cognitive test
BetterBrain app access
75-min dementia consultation
75-minute consultation to review your results and tailor your personalized prevention protocol
A certified provider with a deep background in preventive neurology, all yours for 75 minutes.
We help you navigate the clinical and non-clinical actions to take for your brain health.
SMS coaching with a dementia specialist
Message your dementia prevention specialist anytime for help, for example:
Understanding your test result
Putting your personalized plan into action
Staying motivated and accountable
Choosing the right supplements
Traditional dementia prevention clinics
$2000 – $10 000
Money-Back Guarantee
HSA & FSA Eligible
Buy now, pay later
Better Cognition is Months Away
3 months
BetterBrain users improved key dementia risk markers in just 3 months
When was your last brain check-up?
Dementia can be detected up to 20 years in advance, yet most people with a family history don't check their brain health.
By knowing your numbers, you can address your specific risk factors.
Get peace of mind
Reduce your lifetime risk of Dementia
We will systematically tackle your biggest risks so you minimize your disease risk
Quickly improve your cognitive performance
You can expect noticeable (and measurable) changes within 3 months
Elevate your overall health
Enjoy the whole body health improvements that come with a comprehensive brain health program
No hassle money-back guarantee
Everything we do at BetterBrain is grounded in science. If you experience none of the benefits stated above, we'll refund 100% of your cost. Learn more here.
Discover the top minds behind BetterBrain
With expertise in genetics, neuroscience, epidemiology and heritable diseases,
BetterBrain’s scientific advisors ensure that our prevention program remains
guided by the latest scientific breakthroughs.
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FAQs
What is the APOE4 gene and why does it matter?
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APOE4 is a common variant of the APOE gene, which plays a role in how the body processes fats and cholesterol. Everyone has two copies of the APOE gene—but those who inherit one or two copies of APOE4 face a significantly higher risk of developing Alzheimer’s disease, the most common form of dementia. In fact, carrying APOE4 can increase your risk by up to 20 times.
This increased risk is due to APOE4’s effects on how the brain manages cholesterol, inflammation, and waste removal—especially the buildup of beta-amyloid plaques, which are a hallmark of Alzheimer’s. These biological changes can gradually lead to memory loss, confusion, and difficulty thinking clearly.
That said, carrying APOE4 does not mean you will definitely develop dementia. Lifestyle, diet, sleep, and overall health also play a major role in how your brain ages. Understanding your APOE4 status empowers you to take preventive steps and support long-term brain health.
This increased risk is due to APOE4’s effects on how the brain manages cholesterol, inflammation, and waste removal—especially the buildup of beta-amyloid plaques, which are a hallmark of Alzheimer’s. These biological changes can gradually lead to memory loss, confusion, and difficulty thinking clearly.
That said, carrying APOE4 does not mean you will definitely develop dementia. Lifestyle, diet, sleep, and overall health also play a major role in how your brain ages. Understanding your APOE4 status empowers you to take preventive steps and support long-term brain health.
Does having APOE4 mean I will definitely get Alzheimer's?
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No, having APOE4 does not mean you will definitely develop Alzheimer’s. While APOE4 increases the risk, it does not guarantee that someone will develop the disease. Many people with APOE4 never develop Alzheimer’s, and some without APOE4 do.
Your risk depends on several factors, including:
Your risk depends on several factors, including:
- How many copies of APOE4 you have (one copy raises risk moderately; two copies raise it more significantly)
- Lifestyle choices, such as diet, exercise, sleep, and mental activity.
- Other genetic and health factors that influence brain aging.
Although APOE4 makes Alzheimer’s more likely, healthy habits can help to reduce your risk. Understanding your APOE4 status empowers you to make informed decisions and take proactive steps for lifelong brain health.
Are there benefits to knowing my APOE4 status?
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APOE4 status can be beneficial, especially for making informed decisions about your health and lifestyle. While APOE4 increases the risk of Alzheimer’s, it doesn’t guarantee you will develop it—and there are steps you can take to lower your risk, including joining prevention programs such as BetterBrain’s.
How can I schedule my APOE test?
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BetterBrain’s APOE test is in the form of a blood draw. Testing can be done at any of the 2,000 LabCorp locations across the US. In most cases (98%), you’ll be able to schedule an appointment the next day.
How will my results be delivered to me?
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Your results will be delivered securely through BetterBrain's online portal. You'll receive a notification when they're ready to view. The results are presented in an easy-to-understand format with clear interpretations rather than just raw data. Results will be ready within 2-4 days after the blood draw
Will I get guidance on what to do with my results?
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Yes. If you order the standalone APOE genetic test, we will invite you to a 15-minute consultation with a brain health expert to explain what the results mean and what you might consider to do about it. We believe anyone should be aware of dementia prevention, irrespective of genetic risk. After all, 1 in 2 Alzheimer's cases are preventable. Thats why we developed the BetterBrain check-up, a comprehensive risk assessment and personalized prevention protocol based on latest science. The BetterBrain check-up includes a 75-minute consultation.
How do you keep my health information safe?
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BetterBrain maintains high standards for data privacy and security. Our team includes experienced leaders who have built secure healthcare data systems. All staff are HIPAA-trained, and they implement robust digital, physical, and administrative security measures. BetterBrain restricts access to your results on a need-to-know basis - only you, the ordering physician, and your brain health expert have access to your health data.
What is BetterBrain’s prevention program and why should I join?
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BetterBrain's prevention program offers a comprehensive approach to brain health that includes:
- Holistic assessment with 50+ blood biomarkers and cognitive testing
- Personalized action plans based on your specific risk factors
- Expert coaching with brain health specialists
- Access to curated products and services
- Retesting to track progress
You should join if you're concerned about cognitive decline, have a family history of dementia, or want to optimize your brain health. The program offers significantly more value than traditional medical care for brain health at a fraction of the cost.
How will I know the prevention program is working?
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BetterBrain tracks your progress through:
- Follow-up testing of your most critical biomarkers after 3 months
- Unlimited cognitive assessments to measure improvements in brain function
- Tracking changes in daily functioning, including energy, mood, and clarity
- A personalized dashboard that visualizes your progress
Is BetterBrain covered by insurance?
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BetterBrain is not covered by insurance. However, BetterBrain services are HSA and FSA eligible, which can save you up to 40% on costs depending on your tax bracket.
Is BetterBrain FSA/HSA eligible?
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Yes! BetterBrain is FSA/HSA eligible, allowing you to save up to 40% on the cost.BetterBrain will file a claim on your behalf - no need to use your HSA / FSA card! You will receive an email from our claims partner Binkey with instructions on how to proceed.
Other questions? Feel free to contact us